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The present study was designed to evaluate the efficacy and safety of a single-dose administration of teicoplanin followed by penicillin G treatment for early-phase (prior to abscess formation) methicillin-resistant Staphylococcus aureus (MRSA) skin and skin structure infections (SSSIs). SSSIs were defined as uncomplicated cellulitis, erysipelas or fasciitis in depth, with or without abscess formation. A total of 179 patients enrolled in 24 centres were allocated to receive a single intravenous injection of either 3 mg/kg of body weight teicoplanin (n = 91) or 7.5 million units of penicillin G (n = 88). Among the teicoplanin-treated patients, the resolution rate was 81.2% (n = 70/86) at visit 2 (7 days after treatment) and 92.9% (n = 84/90) at visit 3 (14 days after treatment). In the penicillin G-treated patients, the resolution rate was 70.6% (n = 55/79) at visit 2 and 76.5% (n = 65/84) at visit 3. The proportion of patients with bacterial eradication at day 7 was slightly higher in the teicoplanin-treated group compared to the penicillin G-treated group (91.0 vs. 81.0%, p = 0.085). No differences in terms of local or systemic adverse events were observed. In conclusion, the present results indicate that a
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