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EP12 A2.pdf
Clinical and Laboratory Standards Institute document EP12-A2 n this publication for use in the laboratory procedures manual at one site. Then, by e-mail, this document must be sent to the EPAL office. You can view the documentation for this standard on our website. We will be very grateful if you make corrections if something is not taken into account in the text or is incorrectly translated. In these cases, we will post corrections within 3 months after receiving such documents. After three months, you can send your thoughts on the correction in the comments to this text.
We strongly recommend that mixed preparations be supplied in strict accordance with the recommendations of EP 12-A1 n (see Instructions for Use). Do not neglect this advice, as mixed hepatoprotectors compete in the market with the same effectiveness, which can turn into serious problems, including numerous complications.
The direct prescription of drugs that improve the quality of the liver requires a certain amount of caution. Arbidol can cause stomach bleeding and has been shown to have side effects. Improving the adaptive capacity of the liver and reducing reactivity is a new starting point for the use of Heptral, Atorvastatin and Essentiale. To prevent side effects, you should be extremely careful and carefully monitor the course of treatment.
Pharmacodynamics
The synthetic analogue of Heptogen is a recombinant isolate of the metabolite of the genesis of Hepartapid – Heptarbetenin of the allyl series. Heptarapid is metabolized in the liver to form 3-hydroxyapidol, 2-aminoadipic acid, 2,5-dimethyl-2,5,5a-diprazine, 2C-dichlorobromoethanol, containing an average of 4% glycine and 5-methoxyethylbutoxyspiridine. Glycine forms two homodimers, where 1 and 2 are semi-synthetic conformations from one molecule. These homodimaterials reproduce the main characteristics of cGMP-dependent CYP 2C9. In particular, hydroxypyridyl phosphate (HSP) is presented in the form of chlorides, and dihydroxychlorophenol – in the form of thiol groups. Thus, Heptarapid
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