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In fact, we did not only provide VideoCopilot with an account manager to help you quickly and accurately control your service as defined by the EULA.
The evaluation license is free, and only allows limited use of VideoCopilot itself to create test layouts for your videos.Activating mutations of the p210 BCR-ABL tyrosine kinase domain in patients with chronic myeloid leukemia presenting at a lower range of age.
Chronic myeloid leukemia (CML) is a malignancy of the hematopoietic stem cell characterized by the expression of the BCR-ABL fusion gene produced by a reciprocal translocation between the long arm of chromosome 9 and chromosome 22. Most cases of CML are thought to arise as a result of a single translocation event, but the triggering event of this particular translocation is as yet unknown. There is evidence that suggested that the genetic background of the patients may influence the degree of tyrosine kinase activity associated with p210 BCR-ABL and may contribute to differences in the clinical course of CML. Because patients present with CML at different ages, it has been assumed that age-dependent mechanisms such as genetic background may play a role in the disease course. We have analyzed the constitution of the p210 BCR-ABL tyrosine kinase domain in a series of 146 patients with CML, divided into three age groups, to determine whether there are any age-dependent differences in the composition of the mutant BCR-ABL protein. We have determined the sequence of the tyrosine kinase domain and have analyzed it by the creation of a phylogenetic tree, which indicated that there were several well-defined subgroups of the BCR-ABL sequence, each associated with a clinical entity: the Sokal group and the different international phases. Activating mutations were detected in 51% of the cases. Among the mutations, the V297I mutation (n = 22), the E255K mutation (n = 21), and the A181T/V mutations (n = 16) were found most frequently, especially in those patients aged at presentation less than 25 years. These results indicate that the degree of tyrosine kinase activity in patients with CML is associated with the constitution of
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