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Category:Computer peripherals\] will be employed. Questionnaires will be used to collect demographic information and measure perceived risk.
In addition, an ecological momentary assessment (EMA) will be used to complete the daily online questionnaire every evening for three weeks at home. Participants will be prompted every evening about their tobacco use over the past day. The data from daily questionnaires will be used to compute summary weekly measures of tobacco use (in terms of consumption frequency and usual quantity and type of tobacco) and weekly tobacco product inventory. Questions in daily questionnaires also assess tobacco cessation attempts during the study period.
In addition, cigarettes and other tobacco products including e-cigarettes or e-cigarattes will be measured in participants’ homes using a personal filter sampling device (PFS). Every six weeks, participants will return to the laboratory to provide a saliva sample and collect their cigarettes and other tobacco products. PFS samples will be analyzed for the levels of nicotine and its metabolites, to assess exposure among participants.
Data analysis {#Sec28}
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The primary analysis will compare the within and between groups to assess differences in the self-reported levels of nicotine. A Generalized Linear Mixed Model (GLMM) will be employed. In the GLMM, there will be fixed effects for “Group” (CT + TXT and TET + CTX), “Time”, and “Group x Time” interaction, and a random effect for “Participant ID” to take into account the within-subject correlation of repeated measurements \[[@CR48]\]. The model will not include a covariate for nicotine content due to the lack of a significant between-group difference at baseline.
Main analyses will focus on the primary hypothesis about the interaction of nicotine content, which is if participants receiving TXT are more sensitive to the nicotine level of CT. Given the small sample size, this will be assessed by exploring whether the between-subjects effect for “Group” is significant. Additional exploratory analyses will be performed to assess whether the effect of nicotine content is mediated by experimental group assignment, and whether the effect of nicotine content is moderated by other variables such as depression, cigarette dependence, and self-reported likelihood of using a quitline. A series of contrast codes will be used to assess the effect of experimental conditions on self-reported level of nicotine. If the https://qflash.es/?p=13378
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